EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.348 | Mus musculus | Q8C3P7 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.348 | S-adenosyl-L-methionine + adenine in mRNA | Myc is a direct target of m6A in gaematopoietic stem cells | Mus musculus | S-adenosyl-L-homocysteine + N6-methyladenine in mRNA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.348 | METTL3 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.348 | malfunction | deleting the enzyme (Mettl3) from the adult haematopoietic system leads to an accumulation of haematopoietic stem cell in the bone marrow and marked reduction of reconstitution potential due to a blockage of haematopoietic stem cell differentiation. Deleting Mettl3 from myeloid cells using Lysm-cre does not impact myeloid cell number or function. m6A sequencing reveals 2073 genes with significant m6A modification in haematopoietic stem cells | Mus musculus |
2.1.1.348 | physiological function | the enzyme plays a key role of m6A in governing haematopoietic stem cell differentiation | Mus musculus |